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  • Observational Study
    In-Person

    Spatial Memory based Cognitive Intervention for MCI patients

    What is this Study about?

    This randomized controlled study evaluates the efficacy of a hippocampus-targeted, computerized spatial memory intervention in older adults with Mild Cognitive Impairment (MCI). Participants (≥55 years) will be randomized to either (a) a spatial memory intervention program or (b) an active placebo. Primary outcomes are changes in memory and cognition from baseline to post-training and 6-month follow-up, assessed with standardized neuropsychological measures and validated spatial memory tasks. Secondary outcomes include everyday functioning, quality of life, perceived stress, and related psychosocial indices.  

    A neuroimaging sub-study acquires structural MRI and task-based fMRI to quantify hippocampal morphometry and functional recruitment; we hypothesize training-related improvements will correlate with hippocampal structural/functional change. Exploratory biomarkers (lipids, glucose/insulin for HOMA-IR, cortisol) and polygenic risk scores for dementia are obtained to control inter-individual variability and potential moderators/mediators of training response. The central hypothesis is that sustained, strategy-level engagement of hippocampus-dependent spatial memory will improve cognitive performance in MCI and yield convergent MRI biomarker signatures, supporting experience-dependent plasticity and informing scalable, non-pharmacologic interventions for delaying cognitive decline. 

    Eligibility Criteria

    - Aged 55 years and above 

    - Have English or French as a primary language 

    - Received a diagnosis of Mild Cognitive Impairment (MCI) 

    Recruitment End Date

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  • Observational Study
    In-Person

    Shifting architectures of cognition and brain function in younger and older adults

    What is this Study about?

    Thinking skills (also known as cognitive functions), change from younger to older adulthood. In this study we are investigating how these shifting architectures of cognition and brain function relate to one another, and how these brain and cognitive changes impact decision-making in younger and older adults.

    You may qualify to participate if you are: 1) 60 years of age or older, 2) right-handed, 3) in good health, 4) and have normal or corrected-to-normal vision. Participation will involve completing cognitive tasks, questionnaires, and non-invasive brain measurements using MRI. If you are interested in participating in this study, please contact [email protected]

    Eligibility Criteria

    You are eligible to participate if you:

    - Are aged 60 years or older

    - Are right-handed

    - Are cognitively healthy

    - Are able to come in-person to our site, located at the Montreal Neurological Institute

    - Have no metal in your body (e.g., pacemaker, metal plates, orthopedic devices, etc.)

    - Speak English or French

    Recruitment End Date

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  • Clinical Trial
    In-Person

    Investigating tDCS for people with Alzheimer's Disease or Primary Progressive Aphasia

    What is this Study about?

    We are conducting three separate studies to explore the effects of transcranial Direct Current Stimulation (tDCS) in individuals with Alzheimer’s Disease or Primary Progressive Aphasia. tDCS is a non-invasive therapy that uses low electrical currents to stimulate specific areas of the brain. Previous research has suggested that tDCS can improve symptoms such as language difficulties and may help slow the progression of Alzheimer’s.

    Our studies aim to investigate these effects in different contexts, including language therapy and overall mental abilities. Upon completion, participants will receive their study results to help guide their decisions about whether tDCS could be part of a long-term therapy plan.

    Eligibility Criteria

    Person living with Alzheimer's disease

    Recruitment End Date

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